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Updated: May 2, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and evaluation of (-)-Massoialactone and analogues as potential anticancer and anti-inflammatory agents
Maria E S B Barros1, Juliano C R Freitas1, Juliana M Oliveira1
1Universidade Federal de Pernambuco, Departamento de Química Fundamental, Cidade Universitária, Av. Jornalista Aníbal Fernandes, s/n, Recife, PE 50740-560, Brazil.
Abstract:
(-)-Massoialactone, an α,β-unsaturated δ-lactone isolated from Cryptocarya massoia, and five analogues were synthesized and their antiproliferative and anti-inflammatory activities were evaluated. The lactones were able to mimic the "core" functional group required for the biological activity of their parent natural compounds suggesting that substantially altered analogues may retain their properties.
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