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Updated: May 2, 2026

Identification of the Source of Secreted Proteins in the Kidney by Brefeldin A Injection
Published on: November 10, 2021
Interaction between systemic inflammation and renal tubular epithelial cells
Vincenzo Cantaluppi1, Alessandro Domenico Quercia1, Sergio Dellepiane1
1Nephrology, Dialysis and Kidney Transplantation Unit, Department of Medical Sciences, University of Torino, Turin, Italy.
Abstract:
Systemic inflammation is known to target tubular epithelial cells (TECs), leading to acute kidney injury. Tubular cells have been implicated in the response to inflammatory mediators in ischaemic and septic renal damage. Moreover, loss of tubular cells by apoptosis or epithelial-to-mesenchymal transition may ingenerate conditions that lead to progression towards chronic kidney disease. On the other hand, TECs may actively contribute to the production of inflammatory mediators that may propagate the injury locally or in distant organs. In the present review, we discuss the tubular cell response and its contribution to systemic inflammation.
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