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Toward the ideal synthesis and molecular function through synthesis-informed design.

Paul A Wender1

  • 1Department of Chemistry, Department of Chemical and Systems Biology, Stanford University, CA 94305, USA. wenderp@stanford.edu.

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Summary

Achieving ideal synthesis involves optimizing economies like time and energy, and considering orientations such as safety and function. Synthesis-informed design, guided by function, is key to advancing chemical synthesis and its scientific impact.

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Area of Science:

  • Synthetic chemistry
  • Chemical synthesis optimization
  • Drug discovery

Background:

  • Ideal synthesis balances efficiency and desired outcomes.
  • Current synthetic strategies face challenges in meeting diverse functional requirements.
  • The impact of synthesis on scientific advancement is significant.

Purpose of the Study:

  • To outline key factors for ideal chemical synthesis.
  • To emphasize the role of synthesis-informed design.
  • To highlight the impact of optimized synthesis on scientific progress.

Main Methods:

  • Analysis of economic factors in synthesis (step, time, atom, solvent, energy).
  • Evaluation of orientation factors in synthesis (target, diversity, safety, function).
  • Exploration of synthesis-informed design principles.

Main Results:

  • Identified critical economies and orientations for ideal synthesis.
  • Demonstrated the importance of function-directed design.
  • Highlighted the synergistic relationship between synthesis and scientific advancement.

Conclusions:

  • Optimizing economies and orientations is crucial for ideal synthesis.
  • Synthesis-informed design, focused on function, drives innovation.
  • Advancements in synthesis significantly impact the broader scientific landscape.