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Multiple laser fibers precisely target tumors using laser-induced interstitial thermotherapy (LITT). This study evaluated multifiber LITT in muscle tissue, achieving real-time temperature mapping with MRI for accurate treatment.

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Area of Science:

  • Biomedical Engineering
  • Medical Physics
  • Oncology

Background:

  • Laser-induced interstitial thermotherapy (LITT) offers precise tumor ablation.
  • Optimizing heat delivery and monitoring temperature are crucial for effective LITT.
  • Current methods for temperature monitoring during LITT can be limited.

Purpose of the Study:

  • To investigate the use of multiple fibers for conformal tumor irradiation via LITT.
  • To evaluate the coagulated zones produced in porcine muscle tissue using a multifiber system.
  • To develop and validate a real-time thermometry method for LITT using magnetic resonance imaging (MRI).

Main Methods:

  • A multifiber system capable of using up to four fibers simultaneously was developed.
  • Quantitative MRI based on T1 relaxation time and equilibrium magnetization was used for real-time thermometry.
  • MR-based temperature measurements were compared with fiberoptic thermometer readings in porcine muscle tissue.

Main Results:

  • The multifiber LITT system allowed for controlled power delivery for tissue irradiation.
  • Real-time temperature mapping with MRI achieved an accuracy of 1.5°C in muscle tissue.
  • Single-fiber LITT produced convex isotherms, while multifiber LITT generated concave isotherms, enabling conformal heating.

Conclusions:

  • Multifiber LITT is a viable technique for conformal tumor irradiation.
  • Real-time MRI thermometry provides accurate and rapid temperature monitoring during LITT.
  • The ability to generate concave isotherms with multifiber LITT allows for more precise tumor targeting and ablation.