Pharmacokinetics of 125I-hirudin in rats and dogs

¹Institute of Pharmacology and Toxicology, Medical Academy, Erfurt, GDR.

Folia Haematologica (Leipzig, Germany : 1928)

|January 1, 1988

Abstract:

Hirudin was 125I-labelled using a modified chloramine-T method. 125I-hirudin proved to be a suitable marker in pharmacokinetic studies, if unchanged 125I-hirudin in body fluids was determined by means of a binding assay using immobilized thrombin. In rats and dogs a study was performed on the pharmacokinetic behaviour of hirudin following intravenous and subcutaneous injection, resp., or one-hour infusion and pharmacokinetic parameters were calculated.

Keywords:

anticoagulant protein radioactive labeling drug distribution immobilized thrombin assay

Related Concept Videos

Articles linked to this work by shared authors, journal, and citation graph.

Polarization Measurement of Λ_{c}^{+} and Λ[over ¯]_{c}^{-} Baryons in p-Ne Collisions at sqrt[s_{NN}]=68.6 GeV.

Physical review letters·2026

First Measurement of the Decay-Time-Integrated CP Asymmetry in B_{s}^{0}→D_{s}^{-}π^{+} Decays.

Physical review letters·2026

Study of Nuclear Effects on Charm Production in Light-Ion Collisions.

Physical review letters·2026

First Evidence of the Decay B^{+}→π^{+}e^{+}e^{-}.

Physical review letters·2026

Search for the Lepton-Flavor Violating Decays B^{+}→π^{+}μ^{±}e^{∓}.

Physical review letters·2026

CP Violation Analysis of Local and Nonlocal Amplitudes in the B[over ¯]^{0}→K[over ¯]^{*0}μ^{+}μ^{-} Decay.

Physical review letters·2026

See all related articles

Related Experiment Videos

Pharmacokinetics of 125I-hirudin in rats and dogs

Related Concept Videos

Polarization Measurement of Λ_{c}^{+} and Λ[over ¯]_{c}^{-} Baryons in p-Ne Collisions at sqrt[s_{NN}]=68.6 GeV.

First Measurement of the Decay-Time-Integrated CP Asymmetry in B_{s}^{0}→D_{s}^{-}π^{+} Decays.

Study of Nuclear Effects on Charm Production in Light-Ion Collisions.

First Evidence of the Decay B^{+}→π^{+}e^{+}e^{-}.

Search for the Lepton-Flavor Violating Decays B^{+}→π^{+}μ^{±}e^{∓}.

CP Violation Analysis of Local and Nonlocal Amplitudes in the B[over ¯]^{0}→K[over ¯]^{*0}μ^{+}μ^{-} Decay.

[Recommendations for a medical-meteorologic prognosis for hemophilia].

[Malondialdehyde formation by platelets of hemophiliacs].

Genomic carrier detection and prenatal diagnosis of haemophilia A in families at risk using the polymerase chain reaction (PCR).

Diagnosis of carriers of haemophilia A by RFLP analysis: Austrian results.

Genomic diagnosis of haemophilia A and B in the German Democratic Republic.

[Paradoxical bleeding as a complication of the treatment of hemophilia with factor VIII and factor IX preparations].

Multi-GPU parallel framework for DOI-enabled long axial field-of-view PET image reconstruction.

Proteomics of sperm duct and spermatophore from the ornate spiny lobster, Panulirus ornatus: identifying the precursor of adipokinetic hormone/corazonin-like peptide (ACP).

Evaluation of a canine hemoglobin A1c point-of-care assay: analytical validation, clinical utility, and establishing a population-based reference interval.

Monitoring Calcium Dynamics in Pig Intestinal Organoids with FLIM and FRET.

Exploratory Analysis of Thromboinflammatory and Hematological Changes Following Electrolytic Femoral Vein Injury in Wistar Rats.

Correction: Li et al. Balancing Reproduction and Survival: Seasonal Body Mass Dynamics in a High-Altitude Primate (Rhinopithecus bieti). Animals 2026, 16, 1603.

Related Experiment Videos

Pharmacokinetics of 125I-hirudin in rats and dogs

Abstract:

Related Concept Videos

Related Articles