Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

1.7K
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
1.7K
Antiepileptic Drugs: Glutamate Antagonists01:14

Antiepileptic Drugs: Glutamate Antagonists

1.3K
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
1.3K
Epilepsy ll: Types01:22

Epilepsy ll: Types

47
Recurrent seizures, stemming from abnormal electrical activity in the brain, are the defining characteristic of epilepsy, a chronic neurological condition. Because seizure features vary greatly, epilepsy is classified using two systems: by seizure type and by epilepsy syndromes. These classifications enable clinicians to describe seizure patterns and select suitable treatment strategies.I. Classification by Seizure Type1. Focal EpilepsyFocal epilepsy begins in one hemisphere of the brain.
47
Seizures l: Introduction01:20

Seizures l: Introduction

42
Understanding seizures and epilepsy relies on key definitions that help in recognizing, classifying, and managing these disorders. These definitions provide a framework for recognizing, classifying, and managing seizure disorders.DefinitionsA seizure is a sudden, abnormal burst of electrical activity in the brain that can cause changes in awareness, movement, sensation, or behavior, depending on the area involved. Epilepsy is a chronic condition characterized by recurrent, unprovoked seizures,...
42
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein01:20

Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein

1.2K
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
1.2K
Seizures: Classification01:13

Seizures: Classification

2.5K
Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
2.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity-dependent antioxidant gene therapy protects against epileptogenesis.

Signal transduction and targeted therapy·2026
Same author

Energy metabolism, adenosine, and glutamate signaling reprogramming by decanoic acid in Glut1 disorder syndrome.

Epilepsia open·2026
Same author

The heartbeat evoked potential and the prediction of functional seizure semiology.

Brain communications·2026
Same author

Metabolic targeting of pantothenate by medium chain fats in glioblastoma cells.

BMC cancer·2026
Same author

Dual mechanism of anti-seizure medications in controlling seizure activity.

Brain communications·2026
Same author

Does having bad epilepsy make you a good surgical candidate? A number needed to treat analysis.

Epilepsia open·2026
Same journal

The dual role of mTOR in multiple sclerosis pathophysiology: a systematic review.

Journal of neurology·2026
Same journal

Brain-first versus body-first Parkinson's disease: Differential findings on pupillary, brainstem and vagus sonography.

Journal of neurology·2026
Same journal

Spontaneous intracranial hypotension due to pelvic cerebrospinal fluid leak.

Journal of neurology·2026
Same journal

Morbidity and medication use preceding a diagnosis of late-onset Alzheimer's disease: a Danish nationwide study.

Journal of neurology·2026
Same journal

Comorbid autoimmune disease in stiff-person syndrome spectrum disorder: a systematic review and meta-analysis.

Journal of neurology·2026
Same journal

Tetrahydrocannabinol/cannabidiol in the treatment of restless legs syndrome.

Journal of neurology·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

8.0K

Recent advances in epilepsy.

Stjepana Kovac1, Matthew C Walker

  • 1Institute of Neurology, University College London, London, UK, stjepana.kovac.09@ucl.ac.uk.

Journal of Neurology
|March 5, 2014
PubMed
Summary
This summary is machine-generated.

Recent epilepsy research offers new insights into seizure prediction, mortality, and causes like genetic factors and focal cortical dysplasia. Novel treatments for drug-resistant epilepsy are emerging from advanced experimental techniques.

More Related Videos

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.4K
Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
06:55

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

Published on: November 21, 2024

1.3K

Related Experiment Videos

Last Updated: May 2, 2026

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice
07:01

Electrophoretic Delivery of γ-aminobutyric Acid GABA into Epileptic Focus Prevents Seizures in Mice

Published on: May 16, 2019

8.0K
Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue
06:45

Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

Published on: January 19, 2019

8.4K
Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease
06:55

Author Spotlight: Unraveling Neural Communication and Circuit Interactions in Health and Disease

Published on: November 21, 2024

1.3K

Area of Science:

  • Neurology
  • Epileptology
  • Genetics

Background:

  • Epilepsy research is rapidly evolving, with significant advancements in understanding its causes and treatment.
  • Recent studies address key areas including seizure prediction, mortality, febrile seizures, and focal cortical dysplasia pathophysiology.

Purpose of the Study:

  • To review significant studies from the past 18 months that have advanced the understanding of epilepsies.
  • To highlight breakthroughs in etiological understanding and treatment strategies for various epilepsy types.

Main Methods:

  • Review of recent clinical studies focusing on seizure prediction, epilepsy mortality, febrile seizures, and focal cortical dysplasia.
  • Analysis of advancements in genetics, particularly whole exome sequencing, for understanding epileptic encephalopathies and hippocampal sclerosis.
  • Evaluation of experimental techniques like viral vector gene delivery, optogenetics, and cell transplantation for novel therapeutic approaches.

Main Results:

  • New clinical insights into established epilepsy themes.
  • Enhanced understanding of epileptic encephalopathies and hippocampal sclerosis etiology through genetic advancements.
  • Development of a framework for innovative treatments for pharmacoresistant epilepsy.

Conclusions:

  • Significant strides have been made in epilepsy research over the last 18 months.
  • These advancements span clinical understanding, etiological insights, and the development of novel therapeutic strategies for epilepsy.