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Updated: May 2, 2026

Production and Visualization of Bacterial Spheroplasts and Protoplasts to Characterize Antimicrobial Peptide Localization
Published on: August 11, 2018
Antibacterial activity of pepducins, allosterical modulators of formyl peptide receptor signaling
Malene Winther1, Michael Gabl, Tudor I Oprea
1Department of Rheumatology and Inflammation Research, University of Gothenburg, Gothenburg, Sweden.
Abstract:
Pepducins containing a fatty acid linked to an amino acid sequence derived from cytosolic parts of a G-protein-coupled receptor (GPCR) constitute a new group of lipopeptide tools in GPCR studies. Pepducins corresponding to the third intracellular loop of formyl peptide receptor 2 (FPR2) activate human neutrophils, and we show here that, in addition, these allosteric modulators of receptor activity also kill bacteria. The functional dualism of FPR2 pepducins could potentially be explored as a novel class of antibacterial drugs with immunomodulatory properties.
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