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Updated: May 2, 2026

A Simplified Stepwise Approach to Echo Guidance during Percutaneous Mitral Valve Repair
Published on: October 16, 2021
Advances in interventional cardiology: MitraClip
Said Alsidawi1, Mohamed Effat, Tarek Helmy
1Division of Cardiovascular Health and Disease, College of Medicine, University of Cincinnati, 231 Albert Sabine Way, Cincinnati, OH, 45267, USA, alsidasd@ucmail.uc.edu.
Abstract:
Severe mitral valve regurgitation is a serious condition with significant morbidity and mortality. It is not uncommon recently, to see patients with significant mitral valve regurgitation that are considered "non-surgical candidates" due to their comorbidities. MitraClip is a new percutaneous approach for treating mitral valve regurgitation which involves mechanical edge-to-edge coaptation of the mitral leaflets. In October of 2013, The US Food and Drug Administration (FDA) approved the MitraClip for patients with symptomatic degenerative mitral regurgitation deemed high risk for mitral-valve surgery. Several large clinical trials confirmed the safety and efficacy of MitraClip. We here discuss the growing role of MitraClip, the major clinical trials, the ongoing trials and the potential complications of the procedure.
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