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Self-immolative bioluminogenic quinone luciferins for NAD(P)H assays and reducing capacity-based cell viability
Wenhui Zhou1, Donna Leippe, Sarah Duellman
1Research and Development, Promega Biosciences, Inc. 277 Granada Drive, San Luis Obispo, CA 93401 (USA). wenhui.zhou@promega.com.
Chembiochem : a European Journal of Chemical Biology
|March 5, 2014
Abstract:
Highly sensitive self-cleavable trimethyl lock quinone-luciferin substrates for diaphorase were designed and synthesized to measure NAD(P)H in biological samples and monitor viable cells via NAD(P)H-dependent cellular oxidoreductase enzymes and their NAD(P)H cofactors.
