Significant SNPs have limited prediction ability for thyroid cancer
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Updated: May 2, 2026

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
Published on: February 10, 2023
Shicheng Guo1, Yu-Long Wang, Yi Li
1State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China; Human Genetics Center, University of Texas School of Public Health, Houston, Texas, 77030.
Abstract:
Recently, five thyroid cancer significantly associated genetic variants (rs965513, rs944289, rs116909374, rs966423, and rs2439302) have been discovered and validated in two independent GWAS and numerous case-control studies, which were conducted in different populations. We genotyped the above five single nucleotide polymorphisms (SNPs) in Han Chinese populations and performed thyroid cancer-risk predictions with nine machine learning methods. We found that four SNPs were significantly associated with thyroid cancer in Han Chinese population, while no polymorphism was observed for rs116909374. Small familial relative risks (1.02-1.05) and limited power to predict thyroid cancer (AUCs: 0.54-0.60) indicate limited clinical potential. Four significant SNPs have limited prediction ability for thyroid cancer.
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