Annexin A2: its molecular regulation and cellular expression in cancer development

Area of Science:

• Molecular Biology
• Oncology
• Biochemistry

Background:

• Annexin A2 (ANXA2) is a protein involved in various biological processes.
• Its structure, posttranslational modifications, and proteolytic cleavage critically regulate its function and cellular localization.
• ANXA2 expression is notably altered in various cancer types.

Purpose of the Study:

• To review the multifaceted roles of Annexin A2 (ANXA2) in cancer development.
• To explore the potential of ANXA2 as a diagnostic marker and therapeutic target in oncology.

Main Methods:

• This review synthesizes existing research on Annexin A2.
• It analyzes studies focusing on ANXA2's structure-function relationships, posttranslational modifications, and expression patterns in cancer.
• Literature was examined for ANXA2's involvement in cancer progression, diagnosis, and therapeutic resistance.

Main Results:

• ANXA2's expression levels differ across various cancers, suggesting its potential utility in cancer detection and diagnosis.
• ANXA2 is implicated in key cancer processes, including progression and the development of drug resistance.
• Its activity in cancer development highlights its significance.

Conclusions:

• Annexin A2 (ANXA2) is a significant factor in cancer development and progression.
• ANXA2 holds potential as a biomarker for cancer detection, diagnosis, and monitoring.
• Targeting ANXA2 is a feasible and promising therapeutic strategy for improved cancer management.