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HLA-G polymorphism (rs16375) and acute rejection in liver transplant recipients

Negar Azarpira1, Mahdokht H Aghdaie1, Kurosh Kazemi2

  • 1Organ Transplant Research Center, Namazi Hospital, Shiraz University of Medical Sciences, Zand Street, Shiraz 7193711351, Iran.

Disease Markers
|March 5, 2014
PubMed
Abstract

Insights

The 14 bp insertion/deletion polymorphism (INDEL) in HLA-G does not appear to influence acute rejection in Iranian liver transplant recipients. Further research is needed to explore other genetic markers and HLA-G levels.

Area of Science:

  • Immunogenetics
  • Transplantation Immunology

Background:

  • Human Leukocyte Antigen-G (HLA-G) molecules possess immunomodulatory functions crucial for delaying graft rejection.
  • The 14 bp insertion/deletion polymorphism (INDEL) at rs16375 affects HLA-G mRNA stability and soluble isoform production.

Purpose of the Study:

  • To investigate the association between the HLA-G 14 bp INDEL polymorphism (rs16375) and the incidence of acute rejection in Iranian liver transplant recipients.

Main Methods:

  • Genotyping of the HLA-G 14 bp INDEL polymorphism was performed using PCR.
  • Patients were categorized into acute rejection (AR) and non-acute rejection (NAR) groups based on post-transplant outcomes within six months.

Main Results:

  • No significant differences were observed in demographic factors (sex, MELD score, primary liver disease) between AR and NAR groups.
  • The frequency of rs16375 genotypes and alleles did not differ significantly between the AR and NAR groups (P = 0.44).

Conclusions:

  • The HLA-G 14 bp INDEL polymorphism is not significantly associated with acute rejection in this cohort of Iranian liver transplant recipients.
  • Further investigations into other polymorphic sites and serum HLA-G concentrations are recommended to clarify its role in this population.

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