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Thyroid hormones in pregnancy and preeclampsia
Divya Sardana1, Smiti Nanda1, Simmi Kharb1
1Department of Biochemistry and Obstetrics & Gynecology, Pt.B.D.Sharma, PGIMS, Rohtak. Haryana, India.
Preeclampsia is associated with lower thyroid hormone levels compared to normal pregnancy. Monitoring thyroid hormones and albumin in preeclampsia may help in prevention and management.
Area of Science:
- Endocrinology
- Obstetrics
- Biochemistry
Background:
- Pregnancy involves physiological changes in thyroid hormone levels.
- Preeclampsia is a pregnancy complication with potential endocrine alterations.
Purpose of the Study:
- To investigate thyroid hormone profiles in preeclampsia.
- To identify potential biomarkers for preeclampsia prediction or management.
Main Methods:
- Comparative analysis of thyroid hormones (TT3, TT4, TSH), serum albumin, and uric acid.
- Study included women with preeclampsia, normotensive pregnant women, and non-pregnant women.
Main Results:
- Preeclamptic women showed lower TT3 and TT4 levels than normotensive pregnant women.
- Elevated TSH levels were observed in both preeclamptic and normotensive pregnant women compared to non-pregnant women.
- Negative correlations were found between TSH and birth weight/serum albumin in preeclampsia.
Conclusions:
- Hypothyroxinemia is present in normal pregnancy and preeclampsia.
- Thyroid hormone changes in preeclampsia may offer insights for prevention strategies.
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