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Updated: May 2, 2026
Establishing a Mouse Model of Thin Endometrium
Published on: November 1, 2024
Comparison of serum androgens and endometrial thickness in obese and non-obese postmenopausal women
Ilker İnan Arıkan1, Aykut Barut1, Deniz Arıkan2
1Department of Obstetrics and Gynecology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey.
Objective:
In this study, we investigated whether serum androgen levels and endometrial thickness differed in obese and non-obese women.
Material And Methods:
Thirtytwo non-obese (BMI <30) and 48 obese (BMI ≥ 30) women were enrolled. Blood samples were analyzed for testosterone, free testosterone, androstenedione, DHEAS, and SHBG, and transvaginal ultrasonography was performed.
Results:
Obese women had significantly higher free testosterone and endometrial thickness and significantly lower SHBG. Eight of 17 women with endometrial thickness >5 mm had significant pathology.
Conclusion:
These results suggest that obesity may be a risk factor for endometrial carcinoma and other pathologies in post-menopausal women through an action on androgen concentrations.
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