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Leptin expression in proliferative, secretory and hyperplastic endometrial tissues
Ali Ozler1, Naci Kemal Kuşçu2, Peyker Temiz3
1Department of Obstetrics and Gynecology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey.
Journal of the Turkish German Gynecological Association
|March 5, 2014
Summary
Endometrial leptin expression varies throughout the menstrual cycle, but shows no significant difference in endometrial hyperplasia. This suggests leptin may not be involved in the hyperplastic transformation of the endometrium.
Area of Science:
- Reproductive biology
- Endocrinology
- Gynecologic pathology
Background:
- Leptin, a hormone produced by adipose tissue, also plays roles in reproduction.
- Endometrial leptin expression is known to fluctuate during the menstrual cycle.
Purpose of the Study:
- To investigate endometrial leptin expression during the proliferative and secretory phases.
- To compare endometrial leptin expression in normal cycling endometrium with that of hyperplastic endometrium.
Main Methods:
- Immunohistochemical staining for leptin antibody was performed on endometrial tissue samples.
- Samples included proliferative (n=17), secretory (n=23), and hyperplastic (n=18) endometrium.
- Staining intensity and distribution in glandular epithelium, surface epithelium, and stroma were evaluated.
Main Results:
- Leptin staining intensity increased significantly from the early to late proliferative phase.
- Leptin staining intensity increased significantly from the early to late secretory phase.
- No significant difference in leptin staining intensity was observed among proliferative, secretory, and hyperplastic endometrial tissues.
Conclusions:
- Endometrial leptin expression exhibits differential patterns throughout the menstrual cycle.
- Leptin expression levels in hyperplastic endometrium are comparable to normal proliferative and secretory endometrium.
- Leptin is unlikely to play a significant role in the hyperplastic transformation of the endometrium.
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