Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

2.1K
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
2.1K
Neurulation01:30

Neurulation

40.2K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
40.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fetal Echocardiography and Hyperoxia Testing after Serial Amnioinfusions: Results from the RAFT Trial Bilateral Renal Agenesis Arm.

Fetal diagnosis and therapy·2026
Same author

Neonatal Survival After Serial Amnioinfusions for Anhydramnios Due to Fetal Kidney Failure: The RAFT Clinical Trial.

JAMA·2026
Same author

A Critical Assessment of Antenatal Monitoring for Fetal Well-Being in Down Syndrome Pregnancies.

Diagnostics (Basel, Switzerland)·2026
Same author

Evolving Features of RASopathies Among Pregnancies With Abnormal Fetal Fluid Collections.

Prenatal diagnosis·2025
Same author

Monochorionic, Dizygotic, Sex Discordant Twins With Twin Anemia Polycythemia Sequence.

American journal of medical genetics. Part A·2025
Same author

Cell-free DNA screening results by stage of maternal malignancy.

American journal of obstetrics & gynecology MFM·2025

Related Experiment Video

Updated: May 2, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

10.5K

Perinatal neuroprotection.

Kirsten E Salmeen1, Angie C Jelin2, Mari-Paule Thiet3

  • 1513 Parnassus Avenue, Room HSE-1634, Box 0556, San Francisco, CA 94143-0556 USA.

F1000Prime Reports
|March 5, 2014
PubMed
Summary

Perinatal neuroprotection strategies like magnesium sulfate and hypothermia show promise for preventing newborn brain injury. However, significant challenges remain in reducing preterm birth and repairing existing brain damage.

More Related Videos

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
10:30

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

19.2K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

892

Related Experiment Videos

Last Updated: May 2, 2026

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

10.5K
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy
10:30

A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy

Published on: May 16, 2015

19.2K
Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy
05:52

Early Pathological and Magnetic Resonance Detection of Cerebral Injury Using a Rat Model of Neonatal Hypoxic Ischemic Encephalopathy

Published on: October 28, 2022

892

Area of Science:

  • Neonatal neurology
  • Perinatal medicine
  • Neuroscience

Background:

  • Fetal and neonatal brain injury can lead to lifelong neurological disabilities.
  • Prematurity is a major risk factor, but full-term infants account for the majority of affected children.
  • Current research focuses on neuroprotection to mitigate perinatal brain injury.

Purpose of the Study:

  • To review current strategies for perinatal neuroprotection.
  • To identify promising agents and preventative measures.
  • To highlight existing challenges and future research directions.

Main Methods:

  • Review of established and emerging neuroprotective interventions.
  • Analysis of preventative strategies for preterm and term infants.
  • Examination of agents for neuronal repair and post-injury modulation.

Main Results:

  • Magnesium sulfate and therapeutic hypothermia are established neuroprotective measures.
  • Umbilical cord blood, erythropoietin, delayed cord clamping, progesterone, and infection avoidance show promise.
  • Challenges include reducing preterm birth rates and predicting/treating hypoxic injury in term infants.

Conclusions:

  • Despite advances in perinatal neuroprotection, significant challenges persist.
  • Further research is needed to improve prevention and repair of neonatal brain injury.
  • Perinatal brain injury continues to affect thousands of newborns annually, causing substantial morbidity and mortality.