Related Experiment Video

Updated: May 2, 2026

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
04:39

Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model

Published on: March 17, 2023

2.8K

Prevalence of thyroid autoimmunity in children with celiac disease compared to healthy 12-year olds

Maria van der Pals1, Anneli Ivarsson2, Fredrik Norström2

  • 1Department of Pediatrics, Clinical Sciences, Skåne University Hospital, Lund University, 205 02 Lund, Sweden.

Autoimmune Diseases
|March 5, 2014
PubMed

Insights

Children with celiac disease have a higher risk of thyroid autoimmunity. This study found no increased risk for thyroid autoimmunity in untreated celiac disease, suggesting early treatment may not prevent other autoimmune conditions.

Area of Science:

  • Pediatric autoimmune diseases
  • Endocrinology
  • Gastroenterology

Background:

  • Celiac disease is linked to other autoimmune conditions.
  • The specific relationship between untreated celiac disease and thyroid autoimmunity in children requires further investigation.

Purpose of the Study:

  • To determine the prevalence of thyroid autoimmunity in children with diagnosed and treated celiac disease, newly diagnosed untreated celiac disease, and without celiac disease.
  • To assess if untreated celiac disease increases the risk of developing thyroid autoimmunity.

Main Methods:

  • A cohort study involving 12,632 children.
  • Blood samples analyzed for thyroid peroxidase autoantibodies (TPOAb).
  • Cases of celiac disease (diagnosed and screening-detected) were matched with referents.

Main Results:

  • 335 celiac disease cases identified.
  • 7.2% of children with celiac disease had elevated TPOAb, compared to 2.8% of referents.
  • No significant difference in TPOAb positivity was found between treated and untreated celiac disease groups.

Conclusions:

  • Children with celiac disease exhibit a higher prevalence of thyroid autoimmunity.
  • The study did not support the hypothesis that untreated celiac disease is associated with an increased risk of thyroid autoimmunity.
  • Early celiac disease treatment initiation may not reduce the risk of developing other autoimmune diseases.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

23.9K
A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-1906:46

A High-Throughput Multiplexed Screening for Type 1 Diabetes, Celiac Diseases, and COVID-19

Published on: July 5, 2022

2.6K

Related Concept Videos

Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence...
23
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.4K
Graves Disease II: Pathophysiology01:24

Graves Disease II: Pathophysiology

Graves’ disease is an autoimmune disorder characterized by the production of thyroid-stimulating immunoglobulins (TSI) that activate TSH receptors, leading to excessive synthesis and release of thyroid hormones (T3 and T4) and resulting in hyperthyroidism.Among all causes of hyperthyroidism, Graves’ disease is the most common and can happen at any age, though it is more frequent in women. It produces a hypermetabolic state with features such as weight loss, tachycardia, tremor,...
26
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1...
45
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH...
28
Hyperthyroidism I: Introduction01:25

Hyperthyroidism I: Introduction

Hyperthyroidism is a type of thyrotoxicosis characterized by the thyroid gland's overproduction of the thyroid hormones triiodothyronine (T3) and thyroxine (T4). This hormone excess increases the basal metabolic rate and enhances sensitivity to catecholamines.DiagnosisDiagnosis is based on clinical features and biochemical testing. It typically shows suppressed thyroid-stimulating hormone (TSH) levels below 0.4 mIU/L, with elevated free T3 and/or T4. Additional tests, including thyroid...
30