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Updated: May 2, 2026

Author Spotlight: A Selective Luciferase-Based Assay for Monitoring ATG4B 27 Activity in Cells
Published on: June 30, 2023
Cathepsin C inhibitors: property optimization and identification of a clinical candidate
Mark Furber1, Anna-Karin Tiden, Philip Gardiner
1AstraZeneca , Pepparedsleden 1, Mölndal 431 83, Sweden.
Abstract:
A lead generation and optimization program delivered the highly selective and potent CatC inhibitor 10 as an in vivo tool compound and potential development candidate. Structural studies were undertaken to generate SAR understanding.
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