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Updated: May 2, 2026
11:24
Direct Protein Delivery to Mammalian Cells Using Cell-permeable Cys2-His2 Zinc-finger Domains
Published on: March 25, 2015
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Recent developments in protein and peptide parenteral delivery approaches
Ashaben Patel1, Kishore Cholkar, Ashim K Mitra
1Division of Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, MO 64108, USA.
Therapeutic Delivery
|March 6, 2014
Summary
Improving protein and peptide therapeutics delivery remains a challenge. This review explores chemical modifications and colloidal systems to enhance stability, bioavailability, and efficacy for better patient outcomes.
Area of Science:
- Biotechnology
- Pharmaceutical Sciences
- Drug Delivery
Background:
- The discovery of insulin spurred advancements in therapeutic protein delivery.
- Parenteral administration remains the primary route for protein and peptide therapeutics.
- Enhancing biological half-life, stability, and efficacy is crucial for these drugs.
Purpose of the Study:
- To review current approaches for improving protein and peptide therapeutic delivery.
- To discuss methods enhancing stability, bioavailability, and bioactivity.
- To highlight recent developments in protein and peptide drug delivery systems.
Main Methods:
- Review of chemical modification strategies (e.g., PEGylation, hyperglycosylation, mannosylation).
- Analysis of various colloidal carriers (e.g., nanoparticles, liposomes, micelles).
- Discussion of in situ thermosensitive gel-based delivery systems.
Main Results:
- Chemical modifications and colloidal systems show promise in improving protein and peptide delivery.
- These approaches address challenges in stability, bioavailability, and in vivo performance.
- Recent advancements include novel gel-based systems for sustained release.
Conclusions:
- Various strategies exist to enhance protein and peptide therapeutic delivery.
- Chemical and colloidal approaches offer significant improvements.
- Further research into these delivery systems can optimize therapeutic efficacy.
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