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Related Experiment Video

Updated: May 2, 2026

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

A Revised Method for Inducing Secondary Lymphedema in the Hindlimb of Mice

Published on: November 2, 2019

Chronic progressive lymphoedema in draught horses.

K de Keyser¹, S Janssens, N Buys

¹Livestock Genetics, Department of Biosystems, KU Leuven, Heverlee (Leuven), Belgium.

Equine Veterinary Journal

|March 6, 2014

Summary

Chronic progressive lymphoedema in draught horses causes limb swelling and skin issues. Further research is needed for better diagnostics and treatments for this costly condition.

Keywords:

chronic progressive lymphoedema clinical signs draught horse horse molecular genetics quantitative genetics

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Published on: May 1, 2015

Area of Science:

Veterinary Medicine
Equine Health
Dermatology

Background:

Chronic progressive lymphoedema (CPL) is a multifactorial disorder affecting draught horses, primarily impacting the lower limbs.
Clinical signs include progressive skin deterioration, swelling, and deformation, with significant economic impact.
First reported in the early 20th century, CPL was recognized as a distinct syndrome in 2003, prompting increased research.

Purpose of the Study:

To summarize and evaluate the current state of knowledge regarding chronic progressive lymphoedema in draught horses.
To identify gaps in understanding and areas for future research in CPL.

Main Methods:

Literature review and synthesis of existing research on chronic progressive lymphoedema.
Evaluation of clinical signs, pathogenesis, prevalence, and economic impact.
Assessment of current diagnostic techniques and treatment options.

Main Results:

CPL is characterized by progressive limb swelling and skin changes, with high prevalence in certain breeds.
The exact pathogenesis of CPL remains incompletely understood.
Current treatments for CPL are symptomatic and noncurative, highlighting limitations in management.

Conclusions:

Improved diagnostic techniques for chronic progressive lymphoedema are essential.
Development of selection tools to mitigate the genetic or environmental factors contributing to CPL is needed.
Further research into the pathogenesis and effective treatments for CPL is critical for equine welfare and industry sustainability.