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Spinal cord normalization in multiple sclerosis.

Jiwon Oh1, Michaela Seigo1, Shiv Saidha1

  • 1Department of Neurology, Johns Hopkins University.

Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging
|March 6, 2014
PubMed
Summary
This summary is machine-generated.

Normalizing spinal cord volume (SCV) by length in multiple sclerosis (MS) enhances detection of disease-related differences and strengthens clinical correlations. This method improves the clinical utility of SC-atrophy measures in MS.

Keywords:
MRIMultiple sclerosisatrophynormalizationspinal cord

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Area of Science:

  • Neurology
  • Radiology
  • Biomedical Engineering

Background:

  • Spinal cord (SC) pathology is a key feature of multiple sclerosis (MS).
  • Measures of SC atrophy are increasingly used, but optimal normalization techniques for SC volume (SCV) are unclear.
  • Normalization aims to reduce biological variation unrelated to MS pathology.

Purpose of the Study:

  • To assess the effect of SCV normalization on detecting group differences in MS.
  • To evaluate how SCV normalization impacts clinical-radiological correlations.
  • To determine optimal normalization parameters for SCV in MS research.

Main Methods:

  • Cervical SC-MRI was performed on 133 MS patients and 11 healthy controls (HC).
  • Clinical assessments included EDSS, MSFC, hip-flexion strength, and vibration sensation threshold.
  • SCV was measured and normalized by height, SC length, and intracranial volume (ICV).

Main Results:

  • Normalization by length and height revealed significant group differences (MS vs. HC, progressive vs. relapsing MS).
  • Correlations between clinical measures and SCV strengthened significantly with normalization by length.
  • Normalization by length enabled detection of correlations not apparent with raw SCV in relapsing MS.

Conclusions:

  • SCV normalization by length improves the detection of group differences in MS.
  • Normalization by length enhances clinical-radiological correlations, aiding subtle SC-atrophy detection.
  • SCV normalization by length may increase the clinical utility of SC-atrophy measures in MS.