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Assembly and Characterization of Polyelectrolyte Complex Micelles
Published on: March 2, 2020
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Colloidal micro- and nano-particles as templates for polyelectrolyte multilayer capsules.
Bogdan V Parakhonskiy1, Alexey M Yashchenok2, Manfred Konrad3
1BIOtech Center, Department of Physics, University of Trento, via delle Regole 101, 38123 Mattarello, Italy; Shubnikov Institute of Crystallography, Russian Academy of Science, Leninskii prospekt 59, Moscow 119333, Russia.
Advances in Colloid and Interface Science
|March 6, 2014
Summary
Micro- and nano-particles are key for polyelectrolyte multilayer capsules and drug delivery. Templating methods evolve, with anisotropic particles offering new carrier potential for advanced biomedical applications.
Area of Science:
- Material Science
- Pharmaceutical Science
- Biotechnology
- Biomedicine
Background:
- Colloidal particles are crucial in diverse scientific fields.
- Polyelectrolyte multilayer capsules are prepared using colloidal particles as templates.
- Template selection impacts capsule properties and drug release.
Purpose of the Study:
- To review micro- and nano-particles for polyelectrolyte multilayer capsules.
- To discuss their use as drug delivery vehicles.
- To compare different templating materials and approaches.
Main Methods:
- Adsorption of polymeric layers onto colloidal templates.
- Dissolution of templates to form hollow capsules.
- Comparison of various template materials (melamine formaldehyde, silica, calcium carbonate, red blood cells).
Main Results:
- Template choice influences solvent requirements, porosity, aggregation, and release kinetics.
- Evolution from melamine formaldehyde to silica and calcium carbonate templates.
- Anisotropic particles show promise as independent delivery carriers.
Conclusions:
- Colloidal particles are versatile for creating advanced drug delivery systems.
- Template material selection is critical for optimizing capsule performance.
- Future directions include anisotropic particle development for enhanced drug delivery.
