Improving receiver performance of diffusive molecular communication with enzymes

Area of Science:

• Biochemical Engineering
• Molecular Communications
• Information Theory

Background:

• Intersymbol interference (ISI) is a major challenge in diffusive molecular communication (MC).
• Traditional methods for mitigating ISI in MC are often limited.
• Enzymes offer a potential solution for active molecule degradation in MC systems.

Purpose of the Study:

• To investigate the use of freely diffusing enzymes for mitigating ISI in diffusive MC.
• To develop a theoretical framework for analyzing enzyme-mediated ISI reduction.
• To propose and evaluate a receiver detection scheme utilizing enzyme activity.

Main Methods:

• Derivation of a lower bound expression for the expected number of molecules at the receiver.
• Proposal of a binary receiver detection scheme based on expected molecule arrival time.
• Analysis of expected bit error probability considering enzyme kinetics and previous transmissions.
• Performance evaluation through simulations.

Main Results:

• A novel method for ISI mitigation in diffusive MC using enzymes was demonstrated.
• An accurate expression for expected bit error probability was derived, dependent on past transmissions.
• Simulations confirmed the accuracy of the derived expressions.
• Significant communication performance improvements were observed with active enzymes.

Conclusions:

• Freely diffusing enzymes effectively mitigate intersymbol interference in diffusive molecular communication.
• The proposed receiver design and theoretical analysis provide valuable insights for MC system design.
• Enzyme-mediated degradation offers a promising approach for enhancing the reliability of molecular communication systems.