Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

5.3K
Checkpoints throughout the cell cycle serve as safeguards and gatekeepers, allowing the cell cycle to progress in favorable conditions and slow or halt it in problematic ones. This regulation is known as the cell cycle control system.
Cyclin-dependent kinases, or Cdks, work in concert with cyclins to control cell cycle transitions. M-Cdk, a complex of Cdk1 bound to M cyclin, is a well-known example of this coordinated control that drives the transition from the G2 to the M phase.
M cyclin...
5.3K
M-Cdk Drives Transition Into Mitosis02:15

M-Cdk Drives Transition Into Mitosis

2.5K
2.5K
The Mitotic Spindle02:27

The Mitotic Spindle

7.1K
The mitotic spindle—or spindle apparatus—is a eukaryotic, cytoskeletal structure made up of long protein fibers called microtubules. Formed during cell division, the spindle separates sister chromatids and moves them to opposite ends of a parental cell, where the now individual chromosomes are distributed to two daughter cell nuclei.
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
7.1K
The Mitotic Spindle02:27

The Mitotic Spindle

4.9K
4.9K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

6.3K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.3K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

4.9K
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-cell analyses identify independent aging processes that compete to determine cellular fate in budding yeast.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cell enlargement drives aging-associated proteome remodeling and shortens replicative lifespan.

bioRxiv : the preprint server for biology·2026
Same author

Potassium ion homeostasis modulates mitochondrial function.

The Journal of cell biology·2026
Same author

Dissociation of the nuclear basket triggers chromosome loss in aging yeast.

eLife·2025
Same author

A network of P-body and Whi3 condensates adjusts cell fate decisions to cellular context.

Molecular cell·2025
Same author

Ribosome heterogeneity arising from common and rare rRNA sequence variants affects diverse human phenotypes.

medRxiv : the preprint server for health sciences·2025

Related Experiment Video

Updated: May 2, 2026

Time-lapse Imaging of Mitosis After siRNA Transfection
08:21

Time-lapse Imaging of Mitosis After siRNA Transfection

Published on: June 6, 2010

18.6K

The Mitotic Exit Network: new turns on old pathways.

Manuel Hotz1, Yves Barral1

  • 1Institute of Biochemistry, Biology Department, ETH Zurich, Schafmattstrasse 18, 8093 Zurich, Switzerland.

Trends in Cell Biology
|March 6, 2014
PubMed
Summary

The Mitotic Exit Network (MEN) in budding yeast signals cell cycle progression. This study re-evaluates the MEN

Keywords:
Hippo pathwayMEN polarityMitotic Exit Networkasymmetric cell divisionpre-anaphase functionsspindle asymmetryspindle positioning

More Related Videos

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

13.7K
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

7.8K

Related Experiment Videos

Last Updated: May 2, 2026

Time-lapse Imaging of Mitosis After siRNA Transfection
08:21

Time-lapse Imaging of Mitosis After siRNA Transfection

Published on: June 6, 2010

18.6K
Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis
08:33

Combining Mitotic Cell Synchronization and High Resolution Confocal Microscopy to Study the Role of Multifunctional Cell Cycle Proteins During Mitosis

Published on: December 5, 2017

13.7K
Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations
07:14

Live Cell Imaging to Assess the Dynamics of Metaphase Timing and Cell Fate Following Mitotic Spindle Perturbations

Published on: September 20, 2019

7.8K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Genetics

Background:

  • The Mitotic Exit Network (MEN) is a crucial signaling pathway in budding yeast.
  • MEN regulates the transition from mitosis to cytokinesis by inactivating cyclin-dependent kinase 1 (Cdk1).
  • The established model posits MEN activity is restricted to late anaphase, contingent on spindle pole body (SPB) alignment.

Purpose of the Study:

  • To re-evaluate the established model of the Mitotic Exit Network (MEN).
  • To integrate recent findings suggesting earlier roles for MEN in mitosis.
  • To provide a revised understanding of mitotic exit regulation in budding yeast.

Main Methods:

  • Literature review and synthesis of recent experimental findings.
  • Comparative analysis of existing MEN pathway models.
  • Conceptual integration of new data into the current framework.

Main Results:

  • Evidence suggests MEN activity may initiate prior to late anaphase.
  • The timing and regulation of MEN activation may be more complex than previously thought.
  • Re-evaluation is needed to incorporate potential roles of MEN in earlier mitotic stages.

Conclusions:

  • The current model of MEN function requires revision.
  • MEN's role in mitotic exit may extend beyond late anaphase.
  • Further research is needed to elucidate the precise temporal regulation of MEN.