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Updated: May 2, 2026

In Vitro Analysis of Myd88-mediated Cellular Immune Response to West Nile Virus Mutant Strain Infection
Published on: November 27, 2014
B cell response and mechanisms of antibody protection to West Nile virus
S Kyle Austin1, Kimberly A Dowd2
1Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. skaustin@DOM.wustl.edu.
Abstract:
West Nile virus (WNV) has become the principal cause of viral encephalitis in North America since its introduction in New York in 1999. This emerging virus is transmitted to humans via the bite of an infected mosquito. While there have been several candidates in clinical trials, there are no approved vaccines or WNV-specific therapies for the treatment of WNV disease in humans. From studies with small animal models and convalescent human patients, a great deal has been learned concerning the immune response to infection with WNV. Here, we provide an overview of a subset of that information regarding the humoral and antibody response generated during WNV infection.
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