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Arterial input function sampling without surgery in rats for positron emission tomography molecular imaging.

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Developing minimally invasive arterial input function (AIF) methods using tail artery blood sampling in rats is reliable for preclinical PET imaging. This technique aids pharmacokinetic modeling and myocardial metabolic rate of glucose estimations.

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Area of Science:

  • Preclinical Molecular Imaging
  • Pharmacokinetic Modeling
  • Radiopharmaceutical Dosimetry

Background:

  • Accurate arterial input function (AIF) is crucial for quantitative analysis in positron emission tomography (PET) studies.
  • Traditional methods for AIF derivation can be invasive and technically challenging.
  • Minimally invasive techniques are needed to improve efficiency and reproducibility in preclinical research.

Purpose of the Study:

  • To develop and validate a minimally invasive procedure for deriving AIF in rats via tail artery blood sampling.
  • To assess the utility of a microvolumetric blood counter (μBC) with dispersion correction for AIF analysis.
  • To enable reliable pharmacokinetic modeling in preclinical PET studies.

Main Methods:

  • Simultaneous AIF acquisition from femoral and tail arteries in rats (n=6) using manual and μBC methods post-(18)F-FDG injection.
  • Comparison of AIF shapes and kinetic parameters (Ki, K(1), K(i)) using Patlak and three-compartment models.
  • Validation of AIF derivation using three single-site withdrawal methods (manual tail, μBC tail, μBC femoral) for myocardial metabolic rate of glucose (MMRG) estimation.

Main Results:

  • Simultaneous withdrawal showed similar AIF shapes and influx rate constants (Ki) between femoral and tail arteries (P>0.05).
  • Dispersion-corrected μBC AIFs and manual AIFs demonstrated comparable shapes and kinetic constants (P>0.05) regardless of withdrawal site or method.
  • Kinetic analysis of all three single-site blood sampling methods yielded consistent MMRG values (P>0.05).

Conclusions:

  • Minimally invasive manual blood withdrawal from the tail artery is a reliable method for AIF derivation.
  • Dispersion-corrected μBC-based blood sampling in the tail artery provides a reliable alternative for AIF quantification.
  • Both validated methods support accurate pharmacokinetic follow-up studies within the same animal in preclinical PET imaging.