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Decrease of peripheral resistance after acute intravenous application of a new beta-receptor blocking agents,

D Magometschnigg, J Bonelli, G Hitzenberger

    International Journal of Clinical Pharmacology and Biopharmacy
    |February 1, 1978
    PubMed
    Summary
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    Bufuralol hydrochloride, a new beta-receptor blocking agent, immediately decreases peripheral resistance, unlike pindolol. It maintains constant peripheral resistance during exercise, suggesting a non-beta-blocking effect on peripheral resistance.

    Area of Science:

    • Cardiovascular pharmacology
    • Pharmacodynamics
    • Beta-adrenergic receptor antagonists

    Background:

    • Beta-receptor blocking agents are widely used for cardiovascular conditions.
    • Understanding the specific hemodynamic effects of novel agents is crucial for clinical application.
    • Bufuralol hydrochloride is a new beta-receptor blocking agent with potential therapeutic benefits.

    Purpose of the Study:

    • To compare the hemodynamic effects of bufuralol hydrochloride with those of pindolol.
    • To investigate the impact of these agents on peripheral resistance, particularly under exercise conditions.
    • To explore potential mechanisms underlying bufuralol hydrochloride's effects on peripheral resistance.

    Main Methods:

    • Hemodynamic parameters were measured in subjects receiving bufuralol hydrochloride and pindolol.

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  • Peripheral resistance was assessed both at rest and during exercise.
  • Comparative analysis of the drug effects was performed.

    • Main Results:

    • Bufuralol hydrochloride induced an immediate decrease in peripheral resistance, contrasting with pindolol.
    • During exercise, peripheral resistance increased with pindolol but remained constant with bufuralol hydrochloride.
    • This occurred despite a reduced cardiac output under bufuralol hydrochloride during exercise.

    Conclusions:

    • Bufuralol hydrochloride exhibits distinct hemodynamic effects compared to pindolol, notably on peripheral resistance.
    • The constant peripheral resistance under bufuralol hydrochloride during exercise suggests a potential mechanism independent of peripheral beta-receptor blockade.
    • Further research is warranted to elucidate the non-beta-blocking effects of bufuralol hydrochloride on peripheral resistance.