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Hypertension: is the sham procedure 'toxic' for renal denervation?
1First Cardiology Clinic, University of Athens, Hippokration Hospital, 114 Vassilissis Sofias Avenue, 11527 Athens, Greece.
Nature Reviews. Nephrology
|March 6, 2014
Insights
Renal denervation
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Interventional Cardiology
Background:
- The SYMPLICITY HTN-3 trial's failure to meet its primary endpoint questions the efficacy of renal denervation for blood pressure reduction.
- Despite efficacy concerns, the safety of renal denervation has been established.
Purpose of the Study:
- To evaluate the potential non-antihypertensive benefits of renal denervation on kidney function.
- To explore secondary effects of renal denervation beyond its impact on blood pressure.
Main Methods:
- Analysis of data from the SYMPLICITY HTN-3 trial.
- Assessment of renal function parameters post-renal denervation procedure.
Main Results:
- The SYMPLICITY HTN-3 trial did not achieve its primary blood pressure reduction goals.
- The safety profile of renal denervation was confirmed in the trial.
Conclusions:
- Renal denervation's role in hypertension management requires re-evaluation.
- Further research is warranted to investigate potential renal benefits of renal denervation independent of blood pressure lowering.
Abstract:
The announcement by Medtronic that the SYMPLICITY HTN-3 trial failed to meet its primary effectiveness end point calls the blood pressure lowering effects of renal denervation into question. However, its safety is proven, which raises the possibility that the procedure might have beneficial effects on the kidneys beyond blood pressure reduction.
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