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Related Concept Videos

Acne Infection01:27

Acne Infection

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Acne is a multifactorial skin condition primarily affecting adolescents and young adults, with a global prevalence estimated to exceed 75% in this demographic. The condition is characterized by the formation of comedones (blackheads and whiteheads), papules, pustules, nodules, and, in severe cases, cysts, particularly in areas rich in sebaceous glands such as the face, neck, chest, and back. The pathogenesis involves increased sebum production, follicular hyperkeratinization, colonization by...
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Changes in Skin Color: Clinical Perspectives01:14

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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The Skin Microbiota01:27

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The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
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Healing I: Introduction01:11

Healing I: Introduction

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Healing is the physiological process by which the body restores the integrity and function of damaged tissues following injury. It involves a coordinated interplay of cellular proliferation, extracellular matrix remodeling, and growth factor signaling. The extent and nature of the tissue damage determine whether healing occurs by resolution, regeneration, or replacement.ResolutionResolution represents the most complete form of healing, occurring when the injury is minimal and tissue...
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Drug Administration and Therapy Phases: Overview01:26

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Drugs, the chemical agents used in diagnosing, treating, or preventing diseases, undergo a four-phase process of development: pharmaceutic, pharmacokinetics, pharmacodynamics, and therapeutic.
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Therapeutic Drug Monitoring: Affecting Factors01:29

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Therapeutic Drug Monitoring (TDM) is the clinical practice of measuring specific drug levels in a patient's blood or body tissues to manage and optimize therapy. TDM is crucial for drugs with narrow therapeutic windows, like warfarin and phenytoin, where incorrect doses can lead to treatment failure or severe side effects. This monitoring ensures the dosage administered is within a safe and effective range. The factors affecting therapeutic drug monitoring include:Patient-Specific Factors:a.
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Related Experiment Video

Updated: May 2, 2026

Author Spotlight: Development and Evaluation of a Compound Acne Rodent Model Using C. acnes and Oleic Acid
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Therapeutic update: acne.

Whitney Bowe, Maggie Kober

    Journal of Drugs in Dermatology : JDD
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    Summary
    This summary is machine-generated.

    Effective acne vulgaris treatment requires a patient-centered approach, combining lifestyle changes like dietary counseling with pharmacologic therapies. Emerging treatments and responsible antibiotic use are crucial for managing this common skin condition.

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    Area of Science:

    • Dermatology
    • Pharmacology

    Background:

    • Acne vulgaris is a common, multifactorial skin condition impacting many individuals.
    • A patient-centered approach is essential for effective acne management.
    • Lifestyle interventions and pharmacologic therapies are key components of treatment.

    Purpose of the Study:

    • To review current and emerging therapeutic strategies for acne vulgaris.
    • To emphasize the importance of personalized treatment plans.
    • To discuss the growing need for responsible antibiotic use and alternative therapies.

    Main Methods:

    • Review of current literature on acne vulgaris treatments.
    • Discussion of pharmacologic and non-pharmacologic interventions.
    • Exploration of novel formulations and light-based therapies.

    Main Results:

    • Combination topical therapies are often needed for mixed acne types.
    • Oral medications are indicated for severe or widespread acne.
    • Light-based treatments offer alternative or adjuvant options.
    • Novel drug formulations and compounds are under development.

    Conclusions:

    • Acne treatment requires a tailored approach considering disease severity, bacterial resistance, and patient compliance.
    • Responsible antibiotic stewardship is paramount due to rising resistance.
    • Future therapies hold promise for improved acne management.