Targeted singlet oxygen generation using different DNA-interacting perylene diimide type photosensitizers
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Published on: October 5, 2019
Haluk Dinçalp1, Şevki Kızılok, Sıddık İçli
1Department of Chemistry, Faculty of Arts and Science, Celal Bayar University, Muradiye, 45030, Manisa, Turkey, haluk.dincalp@cbu.edu.tr.
Abstract:
Singlet oxygen quantum yields (ΦΔ) of different perylene diimides (PDIs) containing phenyl (PDI-Ph), pyrene (PDI-Pyr), and indole (PDI-In) units in bay positions of the ring were determined using 1,3-diphenylisobenzofuran (DPBF) method in toluene/methanol (99:1) system. Pyrene-substituted PDI were the most efficient singlet oxygen generator among the investigated photosensitizers with a quantum yield of Φ Δ = 0.93 in toluene/methanol. Additionally, their binding affinities to G-quadruplex DNA structure were investigated by steady-state measurements. There were marked red shifts of absorbance bands for PDI-Pyr/DNA strand complexes with respect to the absorption maxima of DNA-free solution of PDI-Pyr in phosphate buffer at pH 6.
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