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Updated: May 2, 2026

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
Published on: February 16, 2018
Divergent total syntheses of lyconadins A and C
Yang Yang1, Christopher W Haskins, Wandi Zhang
1Department of Chemistry, Purdue University, 560 Oval Drive, West Lafayette, IN 47907 (USA) http://www.chem.purdue.edu/dai/
Abstract:
Divergent and concise total syntheses of two lycopodium alkaloids, lyconadins A and C have been developed. The synthesis of lyconadin A, having potent neurotrophic activity, features an efficient one-pot ketal removal and formal aza-[4+2] cyclization to form the cagelike core structure. A tandem ketal removal/Mannich reaction was developed to build the tricyclic structure of lyconadin C. Both lyconadins A and C were synthesized from a pivotal intermediate.
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