Related Experiment Video
Updated: May 2, 2026
An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
Expression of β-catenin and AXIN2 in ameloblastomas
Zhenhui Wei1, Ming Zhong2, Yan Guo3
1Oral Pathology Department, Oral Medicine College of China Medical University, Shenyang, China 110001 ; Dental Department, No. 463 Hospital of PLA, Shenyang, China 110001.
Aim Of The Study:
To investigate the expression status and association of β-catenin and AXIN2 in ameloblastoma.
Material And Methods:
30 ameloblastoma specimens and 10 normal oral mucosa tissues were enrolled in the study. The protein and RNA levels of β-catenin and AXIN2 were detected by immunohistochemistry staining, Western blot, and real-time PCR analysis. The relationship between β-catenin and AXIN2 protein and clinico-pathological parameters and prognosis was subsequently determined.
Results:
The results show that β-catenin mRNA expression was 1.24-fold higher in ameloblastomas than that in normal mucosa tissues, but AXIN2 mRNA expression was 0.47-fold lower in ameloblastomas than that in normal mucosa tissues (p < 0.05). The Western blot results show that β-catenin and AXIN2 protein in ameloblastomas had a significantly higher level than normal mucosa tissues (p < 0.05). Immunohistochemical staining of β-catenin and AXIN2 protein in ameloblastoma was expressed at a higher level than normal oral mucosa (p < 0.05).
Conclusions:
AXIN2 and β-catenin play an important role in the tumorigenesis and progression of ameloblastoma.
Related Concept Videos
01:23Catenins
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
02:54Canonical Wnt Signaling Pathway
02:54Canonical Wnt Signaling Pathway
01:19Cadherins in Tissue Organization
Cell Sorting During Development
Cell sorting plays an...
01:41Non-Canonical Wnt Signaling Pathways