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Related Experiment Video

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Operant Protocols for Assessing the Cost-benefit Analysis During Reinforced Decision Making by Rodents
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A novel risk-based decision-making paradigm.

Pedro Morgado1, Fernanda Marques1, Miguel B Silva1

  • 1School of Health Sciences, Life and Health Sciences Research Institute (ICVS), University of Minho Braga, Portugal ; ICVS-3Bs PT Government Associate Laboratory Braga/Guimarães, Portugal.

Frontiers in Behavioral Neuroscience
|March 6, 2014
PubMed
Summary
This summary is machine-generated.

Rats chose safe rewards over risky ones unless the risky option was signaled. This novel task effectively studies rodent decision-making under uncertainty.

Keywords:
decision-makingdopamine agonistsenvironmental cuesrisk-takingrodent modelsuncertainty

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Area of Science:

  • Neuroscience
  • Behavioral Economics
  • Animal Cognition

Background:

  • Understanding decision-making under uncertainty is crucial for various fields.
  • Existing tasks often confound uncertainty with expectation or predictability.
  • A novel paradigm is needed to isolate uncertainty in decision-making.

Purpose of the Study:

  • To introduce and validate a new rodent decision-making task.
  • To investigate how rats choose between certain and uncertain rewards.
  • To explore the neural correlates of decision-making under uncertainty.

Main Methods:

  • A 5-hole operating box was used for Wistar rats.
  • Rats chose between a small certain reward and a large uncertain reward.
  • Behavioral choices, reward manipulation effects, drug bias (quinpirole), and c-fos expression in brain regions were analyzed.

Main Results:

  • Rats preferred the certain option when fixed or cued, but showed no preference when the uncertain option was cued.
  • Rats adjusted choices based on perceived reward value changes.
  • The D2/D3 agonist quinpirole shifted choices towards the uncertain option; medial prefrontal cortex, orbitofrontal cortex, nucleus accumbens, and striatum were activated.

Conclusions:

  • The developed task reliably isolates uncertainty in rodent decision-making.
  • Rats exhibit flexible choice strategies influenced by predictability and reward value.
  • Key brain areas involved in decision-making are activated during uncertain choices.