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Decrease of serum Angiotensin converting enzyme levels upon telbivudine treatment for chronic hepatitis B virus

Kung-Hao Liang1, Yi-Cheng Chen1, Chao-Wei Hsu1

  • 1Liver Research Center, Chang Gung Memorial Hospital, Taipei, Taiwan.

Hepatitis Monthly
|March 6, 2014
PubMed
Abstract

Insights

Long-term antiviral therapy for chronic hepatitis B with telbivudine or entecavir reduced serum angiotensin converting enzyme (ACE) levels. Lower ACE levels correlated with improved kidney function (eGFR) in telbivudine-treated patients.

Area of Science:

  • Nephrology
  • Virology
  • Biochemistry

Background:

  • Antiviral therapy for chronic hepatitis B can impact renal function.
  • Nucleoside analogues pose a risk for kidney impairment.
  • Telbivudine treatment paradoxically increased estimated glomerular filtration rate (eGFR).

Purpose of the Study:

  • Investigate changes in serum protein abundances related to renal function during antiviral treatment.
  • Identify mechanisms behind telbivudine's effect on eGFR.

Main Methods:

  • Transcriptomic assay to identify differentially expressed genes with telbivudine.
  • Screened 14 renal function-related genes, focusing on ACE and CFH.
  • Measured serum ACE and CFH levels using enzyme-linked immunoassays.

Main Results:

  • Telbivudine treatment significantly reduced serum ACE levels (P=0.022) and increased eGFR (P=0.002).
  • Serum ACE levels negatively correlated with eGFR in telbivudine-treated patients (r=-0.375, P=0.002).
  • Entecavir also decreased serum ACE levels (P=0.020), but no ACE-eGFR correlation was found.

Conclusions:

  • Oral antiviral monotherapies (telbivudine, entecavir) consistently reduce serum ACE levels.
  • Reduced serum ACE is associated with improved renal function in telbivudine-treated patients.
Keywords:
Antiviral AgentsHepatitis BKidneyNucleosides

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