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Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

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Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
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Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

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Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
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Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

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The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
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Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

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Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
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Lymphatic Vessels and Lymph Transport01:16

Lymphatic Vessels and Lymph Transport

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Lymphatic vessels, known as lymphatics, are crucial in transporting lymph from peripheral tissues to our venous system. This process begins with lymph entering through tiny capillaries that branch through tissues. These capillaries have unique features such as larger diameters, thinner walls, and a distinctive one-way valve system formed by overlapping endothelial cells.
This one-way system allows fluids, solutes, and even pathogens to enter but prevents their return to the intercellular...
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Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

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Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
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Related Experiment Video

Updated: May 2, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

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Intravascular large B cell lymphoma.

Ricardo García-Muñoz1, Susana Rubio-Mediavilla2, Diego Robles-de-Castro1

  • 1Hematology Service, Hospital San Pedro, Logroño, La Rioja, Spain.

Leukemia Research Reports
|March 6, 2014
PubMed
Summary
This summary is machine-generated.

Intravascular large B cell lymphoma (IVBCL) is a rare cancer. Diagnosis can be challenging, but this case highlights key methods for identifying IVBCL in bone marrow and skin.

Keywords:
Intravascular B cell lymphomaLymphomaRituximab maintenance

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Area of Science:

  • Hematology
  • Oncology
  • Dermatology

Background:

  • Intravascular large B cell lymphoma (IVBCL) is a rare extranodal lymphoma.
  • It is characterized by neoplastic lymphocytes confined to the microvasculature.

Purpose of the Study:

  • To present a case of IVBCL.
  • To illustrate diagnostic methods for this rare lymphoma.

Main Methods:

  • Immunophenotyping and polymerase chain reaction (PCR) on bone marrow aspirates.
  • Skin biopsy for histopathological examination.

Main Results:

  • A small monoclonal B cell population was detected in the bone marrow.
  • Skin biopsy confirmed the diagnosis of intravascular large B cell lymphoma.

Conclusions:

  • Early suspicion and combined diagnostic techniques are crucial for IVBCL diagnosis.
  • Immunophenotyping, PCR, and skin biopsy are valuable tools in diagnosing IVBCL.