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Study of Aetiology and Anti-biogram of Uropathogens in Children-A Retrospective Analysis

Dnyaneshwari Purushottam Ghadage1, Swati Shivajirao Nale2, Deepali Shivajirao Kamble3

  • 1Assistant Professor, Department of Microbiology, Kashibai Navale Medical College and General Hospital , Pune, Maharashtra, India .

Journal of Clinical and Diagnostic Research : JCDR
|March 6, 2014
PubMed

Insights

Urinary Tract Infections (UTIs) in children are often caused by E. coli. Resistance to common antibiotics is high, but gentamicin, amikacin, and nitrofurantoin show good sensitivity for treating pediatric UTIs.

Area of Science:

  • Pediatric infectious diseases
  • Microbiology
  • Clinical pharmacology

Background:

  • Urinary Tract Infections (UTIs) represent a significant bacterial infection burden in infants and children.
  • Understanding the specific pathogens and their antimicrobial resistance profiles is crucial for effective treatment strategies.

Purpose of the Study:

  • To investigate the etiological agents responsible for UTIs in pediatric patients.
  • To determine the antimicrobial resistance patterns of common UTI pathogens in children.

Main Methods:

  • An observational study was conducted between 2007 and 2010.
  • 1575 urine samples from children with suspected UTIs were analyzed for demographic characteristics, causative agents, and antibiotic susceptibility.

Main Results:

  • UTIs were more prevalent in males aged 0-1 year and females over 2 years.
  • Escherichia coli was the most frequent pathogen (45.12%), followed by Klebsiella spp. (18.17%) and Enterococcus spp. (9.23%).
  • High resistance rates were observed for ampicillin, co-trimoxazole, and norfloxacin (82%-98%), while gentamicin (83%), amikacin (76.5%), and nitrofurantoin (71.5%) demonstrated significant sensitivity.

Conclusions:

  • E. coli is the predominant pathogen causing UTIs in the pediatric population studied.
  • The high resistance to commonly prescribed antibiotics necessitates consideration of alternative treatments.
  • Gentamicin, amikacin, and nitrofurantoin are potential alternative therapeutic options for pediatric UTIs due to favorable sensitivity profiles.
Abstract

Keywords:
Antibiotic resistanceEscherichia coliSensitivityUrinary tract infection

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