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Published on: August 25, 2019
Effect of underlying infertility factors on second trimester serum screening results
Nermin Köşüş1, Aydin Köşüş2, Müzeyyen Duran2
1Department of Obstetrics and Gynecology, Turgut Ozal University, Faculty of Medicine, Ankara, Turkey. nerminkosus@gmail.com
Objective:
To determine whether assisted reproductive technologies (ART) alone or an underlying cause of infertility has any effect on second trimester serum screening results.
Study Design:
Second trimester serum screening results of ART pregnancies of women with polycystic ovary syndrome (IVF-P group) were compared with those of women who underwent ART due to malefactor infertility (IVF-M group) and of women who conceived spontaneously.
Results:
Comparison of the groups for a-fetoprotein, beta-hCG, and beta-hCG multiples of the median (MoM) revealed a significant difference between the IVF-M and control groups. Comparison of groups for unconjugated estriol (uE3) and uE3 MoM levels revealed a statistically significant difference between the IVF-P versus the control groups.
Conclusion:
It seems advisable to use a population of ART pregnancies, preferably divided by type of treatment and the etiology of the infertility, when establishing median curves for second trimester serum screening markers.
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