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Updated: May 2, 2026
Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
Published on: May 27, 2011
[Immunological cell therapy]
Masahiko Shibata1, Kenji Gonda1, Kensuke Kumamoto2
1Department of Gastroenterological Oncology, International Medical Center, Saitama Medical University.
Recent advances in colorectal cancer treatment include antibody drugs and cancer immunotherapy. This review discusses immunological cell therapies like LAK, CTL, and dendritic cell therapies, and cancer immune escape mechanisms.
Area of Science:
- Oncology
- Immunology
- Pharmacology
Context:
- Colorectal cancer treatment has seen significant advancements.
- Molecular targeting agents, particularly antibody drugs, are crucial.
- Immunotherapy, especially targeting immunological checkpoints, shows promise.
Purpose:
- To review effective cancer immunotherapies.
- To discuss immunological cell therapies.
- To explore cancer immune escape mechanisms.
Summary:
- Antibody drugs and checkpoint inhibitors represent key advances in anti-colorectal cancer therapy.
- Immunological cell therapies, including lymphokine-activated killer (LAK) cells, cytotoxic T lymphocytes (CTLs), gamma delta T cells, and dendritic cell therapies, are reviewed.
- Mechanisms of immune evasion that hinder cancer immunotherapy are also discussed.
Impact:
- Highlights the growing importance of immunotherapy in clinical settings.
- Provides a comprehensive overview of current and emerging cancer immunotherapy strategies.
- Informs future research directions for overcoming cancer's resistance to immunotherapy.
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