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Related Experiment Videos

[Epilepsies from the neurologic viewpoint].

E Ketz1

  • 1Abteilung für Neurophysiologie, Kantonsspital St. Gallen.

Schweizer Archiv Fur Neurologie Und Psychiatrie (Zurich, Switzerland : 1985)
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis·1991
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[Does post-puncture syndrome following lumbar puncture depend on needle diameter?].

Schweizerische medizinische Wochenschrift·1989
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Locked-in state in Borrelia burgdorferi meningitis.

Journal of neurology·1989
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Intestinal toxicoinfection by Clostridium botulinum type F in an adult. Case associated with Guillain-Barré syndrome.

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Therapeutische Umschau. Revue therapeutique·1986

Clinical epileptology has advanced significantly in the last 25 years, with new diagnostic methods, five new antiepileptic drugs, and improved understanding of pharmacokinetics. Treatment now emphasizes monotherapy and therapeutic drug monitoring for better epilepsy management.

Area of Science:

  • Neurology
  • Clinical Epileptology

Context:

  • Review of the last 25 years of clinical epileptology.
  • 100th anniversary of the Clinic for Epileptics Bethesda, Tschugg.

Purpose:

  • To summarize advances in epilepsy classification, pathophysiology, diagnostics, and treatment over the past 25 years.

Summary:

  • No universally accepted epilepsy classification exists.
  • New pathophysiological insights include PDS elucidation, kindling phenomenon, Ca-ion influx theory, and intracerebral metabolic processes.
  • Seven new diagnostic methods and five new antiepileptic drugs have been introduced; 30 drugs were withdrawn.
  • Therapeutic drug monitoring and understanding pharmacokinetics are key advances.
  • Monotherapy is preferred over combination therapy.

Related Experiment Videos

  • Slow-release preparations and calcium-influx blockers are in clinical trials.
  • Progress in pre-operative preparation and surgical therapy for drug-resistant epilepsies.

    • Impact:

    • Improved diagnostic accuracy and therapeutic efficacy in epilepsy management.
    • Enhanced understanding of epilepsy pathophysiology leading to targeted treatments.
    • Optimized drug selection and dosing through pharmacokinetic insights and therapeutic drug monitoring.
    • Advancements in surgical interventions for refractory epilepsy cases.