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Published on: August 16, 2018
A new ursane-type triterpene, cymosic acid from Rosa cymosa
Xiao-Peng Wu1, Xiao-Po Zhang, Guo-Xu Ma
1a College of Pharmaceutical Science, Zhejiang Chinese Medical University , Hangzhou 310053 , China.
Abstract:
A new ursane-type triterpene, cymosic acid (1) together with two known compounds, 3β,19α-dihydroxy-2-oxo-12-ursen-28-oic acid (2) and 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid (3), were isolated from Rosa cymosa Tratt. The structure of compound 1 was elucidated by analyzing its ¹H and ¹³C NMR, ¹H-¹H COSY, HSQC, HMBC, NOESY, and HR-ESI-MS values. The three compounds were found to display moderate inhibitory activities against nitric oxide production in lipopolysaccharide-activated macrophage cell lines, RAW 264.7 cells.
