Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Legal Literacy in Clinical Nursing Practice: A Walker and Avant Concept Analysis.

Nursing reports (Pavia, Italy)·2026
Same author

Clinical study of the preventive effect of pulsed radiofrequency and continuous epidural block on postherpetic neuralgia: a randomized controlled trial.

Frontiers in pain research (Lausanne, Switzerland)·2026
Same author

Effects of dietary supplements on cognitive outcomes and physiological biomarkers in mild cognitive impairment: a systematic review and network meta-analysis.

Frontiers in nutrition·2026
Same author

Interactions Between Exercise Physiology and Metabolism.

Metabolites·2026
Same author

Development of a nursing-sensitive quality evaluation indicator system for perioperative care in breast reconstruction surgery: A Delphi study.

Asia-Pacific journal of oncology nursing·2026
Same author

Cell-specific DNA methylation in human alpha and beta cells regulates gene expression in type 2 diabetes.

Nature metabolism·2026

Related Experiment Video

Updated: May 2, 2026

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
06:45

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

Published on: July 2, 2020

4.1K

Dynamic magnetic fields remote-control apoptosis via nanoparticle rotation.

Enming Zhang1, Moritz F Kircher, Martin Koch

  • 1Department of Clinical Sciences Malmö, Lund University , Malmö 205 02, Sweden.

ACS Nano
|March 7, 2014
PubMed
Summary

Researchers developed a dynamic magnetic field (DMF) generator to control superparamagnetic iron oxide nanoparticles (SPIONs). This technology remotely induces cell death by damaging lysosomes, offering a novel platform for biomedical applications.

More Related Videos

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

4.2K
Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
06:54

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

Published on: July 5, 2022

2.1K

Related Experiment Videos

Last Updated: May 2, 2026

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System
06:45

In Vitro and In Vivo Delivery of Magnetic Nanoparticle Hyperthermia Using a Custom-Built Delivery System

Published on: July 2, 2020

4.1K
Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons
09:54

Fabrication of Magnetic Platforms for Micron-Scale Organization of Interconnected Neurons

Published on: July 14, 2021

4.2K
Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology
06:54

Combining 3D Magnetic Force Actuator and Multi-Functional Fluorescence Imaging to Study Nucleus Mechanobiology

Published on: July 5, 2022

2.1K

Area of Science:

  • Biomedical Nanotechnology
  • Cell Biology
  • Molecular Medicine

Background:

  • Precise remote control of nanoparticles is crucial for nanotechnology applications.
  • Superparamagnetic iron oxide nanoparticles (SPIONs) offer potential for targeted therapies.
  • Lysosomes play a key role in cellular processes and apoptosis.

Purpose of the Study:

  • To investigate the use of dynamic magnetic fields (DMF) to induce rotational movement of SPIONs.
  • To determine if SPIONs can remotely induce cell death by injuring lysosomal membranes.
  • To explore the potential of this technology as a noninvasive therapeutic tool.

Main Methods:

  • Designed a unique dynamic magnetic field (DMF) generator for nanoparticle rotation.
  • Conjugated SPIONs with antibodies targeting LAMP1 (LAMP1-SPIONs) for lysosomal targeting.
  • Applied DMF to induce torque on LAMP1-SPIONs bound to lysosomes in cancer and beta cells.

Main Results:

  • Remote activation of LAMP1-SPIONs enhanced cellular internalization and lysosomal accumulation.
  • Rotational activation of LAMP1-SPIONs caused lysosomal membrane damage via shear forces.
  • Induction of apoptosis was observed, evidenced by increased apoptotic markers and impaired cell growth.

Conclusions:

  • Dynamic magnetic field (DMF) treatment of lysosome-targeted SPIONs provides a noninvasive method for remote apoptosis induction.
  • This technology demonstrates potential as a platform for various biomedical applications.
  • Targeted nanoparticle rotation offers a novel strategy for cancer therapy and other cell-based interventions.