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Retrovirus Life Cycles

Retrovirus Life Cycles

Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...

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Related Experiment Video

Updated: May 2, 2026

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

A Restriction Enzyme Based Cloning Method to Assess the In vitro Replication Capacity of HIV-1 Subtype C Gag-MJ4 Chimeric Viruses

Published on: August 31, 2014

Engineering cellular resistance to HIV

Mark A Kay¹, Bruce D Walker

¹From the Departments of Pediatrics and Genetics, Stanford University School of Medicine, Stanford, CA (M.A.K.); and the Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA (B.D.W.).

The New England Journal of Medicine

|March 7, 2014

Summary

No abstract available in PubMed .

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