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Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Kidney Transplant II: Surgical Procedure01:26

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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Hyperglycemia01:29

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Hyperglycemia is an abnormally high blood glucose level. It is diagnosed by fasting glucose ≥126 mg/dL, 2-hour oral glucose tolerance test (or OGTT) ≥200 mg/dL, random glucose ≥200 mg/dL with symptoms, or HbA1c ≥6.5%. However, HbA1c results may be unreliable in certain conditions, such as anemia or hemoglobinopathies, and the diagnosis should be confirmed unless classic symptoms are present. Postprandial hyperglycemia is typically considered significant when glucose...
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Complications of Diabetes Mellitus01:22

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Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
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Updated: May 2, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
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Deceased donor hyperglycemia and liver graft dysfunction.

Silvia E Perez-Protto1, Luke F Reynolds2, Jarrod E Dalton1

  • 1Cleveland Clinic, Ohio.

Progress in Transplantation (Aliso Viejo, Calif.)
|March 7, 2014
PubMed
Summary

Hyperglycemia in deceased organ donors did not significantly impact liver graft dysfunction after transplant. Controlling donor glucose levels is unlikely to improve graft quality in liver transplantation.

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Area of Science:

  • Transplantation immunology
  • Organ donor management
  • Metabolic disorders

Background:

  • Hyperglycemia is frequently observed in deceased organ donors.
  • High blood glucose levels can trigger adverse effects in liver cells (hepatocytes) and their mitochondria.

Purpose of the Study:

  • To investigate the association between hyperglycemia in deceased donors and the incidence of liver graft dysfunction following orthotopic liver transplantation.

Main Methods:

  • A retrospective review of 572 liver transplants performed between 2005 and 2010.
  • Graft dysfunction defined by primary nonfunction (death/retransplant) or elevated AST/prolonged PT.
  • Multivariable logistic regression analyzed time-weighted donor glucose averages.

Main Results:

  • The overall incidence of liver graft dysfunction was 25%.
  • No statistically significant relationship was found between donor glucose levels and graft dysfunction after adjusting for donor characteristics.
  • The adjusted odds ratio for graft dysfunction with a doubling of donor glucose was 1.43 (95% CI, 0.89-2.30).

Conclusions:

  • The study findings do not support the hypothesis that hyperglycemia in deceased donors is a significant predictor of liver graft dysfunction.
  • Strict glucose control in organ donors is unlikely to enhance liver graft quality for transplantation.