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MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...

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Related Experiment Video

Updated: May 2, 2026

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer

Published on: March 14, 2019

[Progress of study on circulating microRNAs in hematologic malignancies].

Ying Qu¹, Hai-Yan He¹, Jian Hou¹

¹Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai 200003, China.

Zhongguo Shi Yan Xue Ye Xue Za Zhi

|March 7, 2014

Summary

Circulating microRNAs (miRNAs) in body fluids show potential as non-invasive biomarkers for diagnosing and predicting outcomes in hematologic malignancies. These small RNAs offer new avenues for cancer research and treatment.

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An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

Area of Science:

Molecular Biology
Oncology
Biochemistry

Context:

MicroRNAs (miRNAs) are crucial regulators in tumor pathogenesis and progression.
Stable circulating miRNAs have been detected in various human body fluids.
Circulating miRNA profiles correlate with hematologic malignancy types and prognosis.

Purpose:

To review the role of circulating microRNAs in hematologic malignancies.
To discuss the existence patterns and functions of circulating miRNAs.
To explore their potential as diagnostic and prognostic biomarkers.

Summary:

This review examines circulating microRNAs (miRNAs), small non-coding RNAs found stably in body fluids.
It details their presence, patterns, and functions, particularly in relation to hematologic malignancies.
The potential of circulating miRNAs as non-invasive biomarkers for diagnosis and prognosis is highlighted.

Impact:

Circulating miRNAs represent a novel class of biomarkers for hematologic malignancies.
They offer potential for non-invasive diagnostics and prognostics.
These miRNAs may also serve as future therapeutic targets in hematologic cancers.