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Plasma melatonin levels in psoriasis.

N Mozzanica1, G Tadini, A Radaelli

  • 1Second Department of Dermatology, University of Milan, Italy.

Acta Dermato-Venereologica
|January 1, 1988
PubMed
Summary
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Psoriatic patients exhibit disrupted melatonin secretion patterns, lacking the typical nocturnal peak. This hormonal imbalance in psoriasis warrants further investigation into its clinical significance.

Area of Science:

  • Endocrinology
  • Chronobiology
  • Dermatology

Background:

  • Melatonin, secreted by the pineal gland, displays a daily rhythm crucial for physiological processes.
  • Altered hormone chronobiology, including growth hormone (GH) and prolactin, is observed in psoriasis.
  • Existing research suggests a link between melatonin and GH/prolactin levels in humans.

Purpose of the Study:

  • To investigate the circadian rhythm of melatonin secretion in male patients with psoriasis.
  • To compare melatonin secretion patterns between psoriatic individuals and healthy controls.

Main Methods:

  • Radioimmunoassay (RIA) was used to measure plasma melatonin levels.
  • Blood samples were collected from 13 male psoriatics and 13 healthy males at six time points: 6 a.m., 8 a.m., 12 p.m., 4 p.m., 8 p.m., and 2 a.m.

Related Experiment Videos

  • Plasma melatonin levels were analyzed using Student's t-test.

    • Main Results:

    • Psoriatic patients demonstrated a loss of the nocturnal melatonin peak and overall circadian rhythm.
    • Significantly lower melatonin levels were observed in psoriatics at 2 a.m. compared to controls.
    • Conversely, psoriatic patients showed higher melatonin levels at 6 a.m., 8 a.m., and 12 noon.

    Conclusions:

    • Psoriasis is associated with a significant disruption in the normal circadian rhythm of melatonin secretion.
    • The observed alterations in melatonin secretion in psoriatic patients require further research to elucidate their role and implications.
    • Understanding this melatonin secretion disorder may offer new insights into psoriasis pathophysiology.