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Acne fulminans with bone lesions.

S L Pauli¹, M L Kokko, R Suhonen

¹Department of Dermatology, Central Hospital of Tampere, Finland.

Acta Dermato-Venereologica

|January 1, 1988

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Acne fulminans in young men can cause severe bone lesions and musculoskeletal pain. This rare condition may involve immune system responses, not bacterial infections.

Area of Science:

Dermatology
Rheumatology
Pathology

Background:

Acne fulminans is a rare, severe variant of acne vulgaris.
It presents with acute febrile illness and characteristic skin lesions.

Observation:

Five young men with acne fulminans experienced musculoskeletal symptoms.
Radiographic and bone scan imaging revealed osteolytic bone lesions in four patients.
The condition was unresponsive to antibiotics, with one requiring sternal trepanation.

Findings:

Bacteriological cultures were negative, ruling out sepsis or bacterial osteomyelitis.
Histopathology showed unspecific tissue reactions.
The bone lesions appeared to be dermatopathogenetically linked to acne fulminans.

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Implications:

The findings suggest a potential immune-mediated etiology for bone involvement in acne fulminans.
Further research into immune mechanisms is warranted.
This highlights the importance of considering systemic complications in acne fulminans.