Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

94
Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
94
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

25
Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
Viruses with RNA Genomes01:29

Viruses with RNA Genomes

1.5K
RNA viruses are categorized into positive-strand, negative-strand, or double-stranded groups based on their genomic structure and replication mechanisms. This classification dictates how they exploit host cellular machinery for protein synthesis and replication. Some RNA viruses also utilize reverse transcription as part of their life cycle, further diversifying their replication strategies.Positive-Strand RNA VirusesPositive-strand RNA viruses have genomes that function directly as messenger...
1.5K
Human Virome01:26

Human Virome

47
The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible...
47
Viruses of Archaea01:29

Viruses of Archaea

704
Archaeal viruses play a crucial role in the ecosystems of extremophilic archaea, particularly those belonging to the phyla Euryarchaeota and Crenarchaeota. By shaping host evolution and facilitating gene transfer, these viruses influence microbial communities and contribute to genetic diversity in extreme environments. The archaea they infect thrive in acidic hot springs and hydrothermal vents characterized by high temperatures and low pH. Archaeal viruses exhibit remarkable structural...
704
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

102
Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

BECC-adjuvanted hemagglutinin influenza vaccine promotes enhanced immunogenicity and protective efficacy.

Vaccine·2026
Same author

A SARS-CoV-2 entry inhibitor trimerizes to lock the spike protein in a closed conformation.

bioRxiv : the preprint server for biology·2026
Same author

The mammalian SKI complex is a broad-spectrum antiviral drug target that upregulates cellular cholesterol to inhibit viral replication.

Journal of virology·2025
Same author

Discovery, phylogenetic, and comparative genomic analysis of novel avian gammacoronaviruses identified in feral pigeons (<i>Columba livia domestica</i>).

Journal of virology·2025
Same author

An ultra-long heavy chain bovine antibody neutralizes SARS-CoV-2 and reacts broadly with sarbecoviruses.

bioRxiv : the preprint server for biology·2025
Same author

Global siRNA screen identifies human host factors critical for SARS-CoV-2 replication and late stages of infection.

PLoS biology·2025
Same journal

Dysregulation of miRNAs has broad impacts on virus infection in <i>Drosophila</i>.

Journal of virology·2026
Same journal

Identification of GRP78 as a novel host factor that facilitates zoonotic porcine deltacoronavirus internalization and replication via clathrin-mediated endocytosis.

Journal of virology·2026
Same journal

MGF110-2L deletion prevents IFN-I and inflammatory response, resulting in partial attenuation and protection against virulent ASFV.

Journal of virology·2026
Same journal

Periodic genome sequences facilitate packaging in a single-stranded DNA virus.

Journal of virology·2026
Same journal

A novel monoclonal antibody targeting the hemagglutinin-neuraminidase of peste des petits ruminants virus maintains neutralizing activity by blocking viral adsorption and receptor interaction.

Journal of virology·2026
Same journal

ATG9A is an essential host factor for parechovirus RNA replication.

Journal of virology·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

2.4K

Coronaviruses: important emerging human pathogens.

Christopher M Coleman1, Matthew B Frieman

  • 1Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Journal of Virology
|March 7, 2014
PubMed
Summary
This summary is machine-generated.

Researchers compare Middle East respiratory syndrome coronavirus (MERS-CoV) and severe acute respiratory syndrome coronavirus (SARS-CoV) to understand coronavirus emergence and pathogenesis. This comparison highlights key similarities and differences, informing future research on MERS-CoV.

More Related Videos

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

60.1K
Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

16.3K

Related Experiment Videos

Last Updated: May 2, 2026

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions
09:02

Infection of Primary Nasal Epithelial Cells Grown at an Air-Liquid Interface to Characterize Human Coronavirus-Host Interactions

Published on: September 22, 2023

2.4K
Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
08:40

Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting

Published on: March 1, 2019

60.1K
Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells
10:03

Generation of Recombinant Arenavirus for Vaccine Development in FDA-Approved Vero Cells

Published on: August 1, 2013

16.3K

Area of Science:

  • Virology
  • Infectious Diseases
  • Public Health

Background:

  • The emergence of Middle East respiratory syndrome coronavirus (MERS-CoV) in 2012 underscored the need to study coronavirus origins and disease mechanisms.
  • Severe acute respiratory syndrome coronavirus (SARS-CoV) provides a valuable comparative model for understanding MERS-CoV.

Purpose of the Study:

  • To compare the known characteristics of SARS-CoV with recent findings on MERS-CoV.
  • To identify similarities and differences between SARS-CoV and MERS-CoV relevant to disease pathogenesis.
  • To highlight existing knowledge gaps, particularly concerning MERS-CoV.

Main Methods:

  • Comparative analysis of existing scientific literature on SARS-CoV and MERS-CoV.
  • Review of recent research findings on MERS-CoV emergence, infection, and disease.
  • Identification of key areas for future research.

Main Results:

  • Similarities and differences in viral emergence and pathogenesis between SARS-CoV and MERS-CoV have been identified.
  • The comparison provides insights into the potential mechanisms of MERS-CoV infection and disease.
  • Specific knowledge gaps regarding MERS-CoV have been delineated.

Conclusions:

  • Understanding coronavirus pathogenesis requires comparative studies, as exemplified by SARS-CoV and MERS-CoV.
  • Further research is crucial to address the identified knowledge gaps for MERS-CoV.
  • Comparative virology is essential for predicting and mitigating future coronavirus outbreaks.