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Serum endostatin concentrations are higher in men with symptoms of intermittent claudication

Jonathan Golledge1, Paula Clancy2, Graeme J Hankey3

  • 1The Vascular Biology Unit, Queensland Research Centre for Peripheral Vascular Disease, School of Medicine and Dentistry, James Cook University, Townsville, QLD 4811, Australia ; Department of Vascular and Endovascular Surgery, The Townsville Hospital, Townsville, QLD 4814, Australia.

Disease Markers
|March 7, 2014
PubMed

Insights

Serum endostatin levels are higher in older men experiencing intermittent claudication, a symptom of peripheral artery disease. Further research is needed to understand endostatin's role in this condition.

Area of Science:

  • Biochemistry
  • Vascular Biology
  • Gerontology

Background:

  • Endostatin, a collagen XVIII fragment, exhibits antiangiogenic properties in preclinical models.
  • Peripheral artery disease (PAD) affects lower limb circulation, with intermittent claudication as a key symptom.

Purpose of the Study:

  • To investigate the association between circulating endostatin levels and intermittent claudication in older men.
  • To test the hypothesis that higher endostatin levels correlate with symptoms of lower limb PAD.

Main Methods:

  • A cross-sectional study involving community-dwelling older men.
  • Intermittent claudication assessed via the Edinburgh Claudication Questionnaire (ECQ).
  • Serum endostatin measured using ELISA, with logistic regression analysis adjusting for cardiovascular risk factors.

Main Results:

  • Serum endostatin concentrations were significantly higher in men with intermittent claudication (145.22 ± 106.93 ng/mL) compared to those with atypical pain or no lower limb pain (P < 0.001).
  • A 70 ng/mL increase in endostatin was associated with a 1.17-fold increased odds of intermittent claudication (OR 1.17, P = 0.050).

Conclusions:

  • Elevated serum endostatin is observed in older men with intermittent claudication symptoms.
  • The precise role of endostatin in the development and progression of peripheral artery disease warrants additional investigation.
Abstract

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