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Updated: May 2, 2026

Intravascular Delivery of Biologics to the Rat Kidney
Published on: September 1, 2016
Revascularization as a treatment to improve renal function
Helen V Alderson1, James P Ritchie1, Philip A Kalra1
1The University of Manchester, Manchester Academic Health Sciences Centre, Vascular Research Group, Department of Renal Medicine, Salford Royal NHS Foundation Trust, Salford, UK.
Insights
Atherosclerotic renovascular disease (ARVD) is increasing. This review examines current evidence on managing ARVD, focusing on revascularization to improve kidney function, despite inconsistent trial results.
Area of Science:
- Cardiology
- Nephrology
- Vascular Surgery
Background:
- Atherosclerotic renovascular disease (ARVD) prevalence is rising due to an aging population.
- Medical management for atherosclerotic conditions has advanced.
- Endovascular revascularization is available but lacks consistent evidence of benefit for ARVD.
Purpose of the Study:
- To review the current evidence for managing ARVD.
- To focus on revascularization as a treatment to improve renal function.
- To provide an overview of ARVD's impact on kidney function.
Main Methods:
- Review of published randomized controlled trials and existing literature on ARVD.
- Analysis of evidence for revascularization in ARVD and other renal artery stenosis causes.
- Synthesis of current best practices in ARVD patient management.
Main Results:
- Inconsistent evidence exists regarding the benefits of endovascular revascularization in ARVD.
- There is no clear consensus on patient selection for revascularization procedures.
- Published trials offer varying clarity and success in guiding best practice.
Conclusions:
- Further research and clearer guidelines are needed for optimal ARVD management.
- Patient selection for revascularization remains a critical challenge.
- Revascularization's role in improving renal function in ARVD requires more definitive evidence.
Abstract:
An aging atherosclerosis-prone population has led to an increase in the prevalence of atherosclerotic renovascular disease (ARVD). Medical management of this disease, as with other atherosclerotic conditions, has improved over the past decade. Despite the widespread availability of endovascular revascularization procedures, there is inconsistent evidence of benefit in ARVD and no clear consensus of opinion as to the best way to select suitable patients for revascularization. Several published randomized controlled trials have attempted to provide clearer evidence for best practice in ARVD, but they have done so with varying clarity and success. In this review, we provide an overview of ARVD and its effect on renal function. We present the currently available evidence for best practice in the management of patients with ARVD with a particular focus on revascularization as a treatment to improve renal function. We provide a brief overview of the evidence for revascularization in other causes of renal artery stenosis.
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