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High plasma fatty acid concentrations were present in non-diabetic patients with coronary heart disease

Na Yang1, Shuren Guo1, Fang Zheng1

  • 1Center for Gene Diagnosis, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China.

Clinical Laboratory
|March 8, 2014
PubMed

Insights

Elevated free fatty acids (FFAs) are independent risk factors for coronary heart disease (CHD) in non-diabetic individuals. This study highlights FFAs as key indicators for CHD, even without diabetes.

Area of Science:

  • Biochemistry
  • Cardiology
  • Metabolomics

Background:

  • Free fatty acids (FFAs) are linked to coronary heart disease (CHD), but their role in non-diabetic patients requires clarification.
  • Previous studies often included diabetic patients, confounding the association between FFAs and CHD.
  • Carbohydrate response element binding protein (ChREBP) regulates FFA synthesis, making its methylation a potential factor in FFA-related CHD.

Purpose of the Study:

  • To determine if FFAs are independent discriminators of CHD in non-diabetic patients.
  • To investigate the association between FFA concentrations and the DNA methylation of ChREBP in non-diabetic CHD patients.

Main Methods:

  • Collected blood samples from 60 controls and 68 non-diabetic CHD patients after an overnight fast.
  • Measured plasma concentrations of glucose, lipids (TC, TG, HDL-C, LDL-C), and nine types of FFAs using standard biochemical analysis and HPLC.
  • Analyzed DNA methylation of ChREBP via direct bisulfate sequencing.

Main Results:

  • Non-diabetic CHD patients exhibited significantly higher plasma concentrations of TC, TG, and FFAs compared to controls.
  • Logistic regression identified all FFAs except C14:0 as independent risk factors for CHD in this cohort.
  • No significant differences in clinical chemistry indicators were observed between methylated and unmethylated ChREBP groups.

Conclusions:

  • Plasma FFA concentrations are elevated in non-diabetic patients with CHD.
  • FFAs serve as emerging independent discriminators for CHD, playing a significant role even in the absence of diabetes.
Abstract

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